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pH 2013 - Bibliografia - DiFrancesco


n. 2, luglio-dicembre 2013
n. 2, July-December 2013

Bibliografia supplementare - Supplemental references

Ph 2/2013

La corrente “funny” del pacemaker cardiaco
The “funny” current of cardiac pacemaker

Dario DiFrancesco

1. Weidmann S. Effect of current flow on the membrane potential of cardiac muscle. J Physiol 1951; 115:227-36.
2. DiFrancesco D, McNaughton PA. The effects of calcium on outward membrane currents in the cardiac Purkinje fibre. J Physiol 1979; 289:347-73.
3. DiFrancesco D, Noma A, Trautwein W. Kinetics and magnitude of the time-dependent potassium current in the rabbit sinoatrial node: effect of external potassium. Pflugers Arch 1979; 381:271-9.
4. DiFrancesco D, Ojeda C. Properties of the current if in the sino-atrial node of the rabbit compared with those of the current iK2, in Purkinje fibres. J Physiol 1980; 308:353-67.
5. DiFrancesco D. A study of the ionic nature of the pace-maker current in calf Purkinje fibres. J Physiol 1981; 314:377-93.
6. DiFrancesco D. Evidence that IK2 in Purkinje fibres is an inward current activated on hyperpolarization. J Physiol 1980; 305:64-5P.

- DiFrancesco D, Noble D. If IK2 is an inward current, how does it display potassium specificity? J Physiol 1980; 305:14-5P.
- DiFrancesco D. The pacemaker current IK2 in Purkinje fibres is carried by sodium and potassium. J Physiol 1980; 308:32-3P.
- DiFrancesco D, Noble D. Reconstruction of Purkinje fibres currents in sodium-free solution. J Physiol 1980; 308:35-6P.
- DiFrancesco D, Noble D. Implications of the re-interpretation of IK2 for the modelling of the electrical activity of pace-maker tissues in the heart. In: Bouman LN, Jongsma HB (eds). Cardiac Rate and Rhythm. The Hague: Martinus Nijhoff, 1982:93-128.

7. Noble D The surprising heart: a review of recent progress in cardiac electrophysiology. J Physiol 1984; 353:1-50.

- Noble D. The Selected Papers of Denis Noble CBE FRS. In: Noble D, Chen Z, Auffray C, Werner E. (eds). A Journey in Physiology Towards Enlightenment. Imperial College Press, 2011

8. DiFrancesco D, Ferroni A, Mazzanti M, Tromba C. Properties of the hyperpolarizing-activated current (if) in cells isolated from the rabbit sino-atrial node. J Physiol 1986; 377:61-88.
9. Gaskell WH. On the action of muscarine upon the heart, and on the electrical changes in the non-beating cardiac muscle brought about by stimulation of the inhibitory and augmentor nerves. J Physiol 1887; 8:404-15.
10. Loewi O. Über humorale Übertragbarkeit der Herznervenwirkung. Pfl ügers Arch 1921; 189:239-42.
11. Garnier D, Nargeot J, Ojeda C, Rougier O. The action of acetylcholine on background conductance in frog atrial trabeculae. J Physiol 1978; 274:381-96.

- Hoffman BF, Suckling EE. Cardiac cellular potentials. Effect of vagal stimulation and acetylcholine. Am J Physiol 1953; 173:312-20.
- Hutter O, Trautwein W. Vagal and sympathetic effects on the pacemaker fibres in the sinus venosus of the heart. J Gen Physiol 1956; 39:715-33.
- Noma A, Trautwein W. Relaxation of the ACh-induced potassium current in the rabbit sino-atrial node. Pflugers Arch 1978; 377:193-200.
- Sakmann B, Noma A, Trautwein W. Acetylcholine activation of single muscarinic K+ channels in isolated pacemaker cells of the mammalian heart. Nature 1983; 303:250-3.

12. Robinson RB, Siegelbaum SA. Hyperpolarization-activated cation currents: from molecules to physiological function. Annu Rev Physiol 2003; 65:453-80.
13. DiFrancesco JC, Barbuti A, Milanesi R, et al. Recessive loss-of-function mutation in the pacemaker HCN2 channel causing increased neuronal excitability in a patient with idiopathic generalized epilepsy. J Neurosci 2011; 31:17327-37.
14. Bucchi A, Baruscotti M, DiFrancesco D. Current-dependent block of rabbit sino-atrial node If channels by ivabradine. J Gen Physiol 2002; 120:1-13.
15. DiFrancesco D, Camm JA. Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease. Drugs 2004; 64:1757-65.
16. Fox K, Ford I, Steg PG, et al. Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a subgroup analysis of a randomised controlled trial. Lancet 2008; 372:817-21.
17. Swedberg K, Komajda M, Bohm M, et al. Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study. Lancet 2010; 376:875-85.
18. Cappato R, Castelvecchio S, Ricci C, et al. Clinical efficacy of ivabradine in patients with inappropriate sinus tachycardia: a prospective, randomized, placebo-controlled, double-blind, crossover evaluation. J Am Coll Cardiol 2012; 60:1323-9.
19. Brown H, DiFrancesco D. Voltage-clamp investigations of membrane currents underlying pace-maker activity in rabbit sino-atrial node. J Physiol 1980; 308:331-51.



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